"The drone strike this night targeted a car carrying al Qaeda regional leaders Mohammed Jabir al-Shabwani and Abdullah Mubarak bin Hamad in Wadi Abida area of Marib," Xinhua quoted the official as saying while requesting anonymity.
It was fourth drone strike within a week that targets al Qaeda suspects inside Yemen.
On Wednesday, a US unmanned plane hit a vehicle in the Yemeni northern province of al- Jawf and killed at least two suspected Al Qaeda militants. Two days earlier, another drone strike killed a suspected al Qaeda militant in Marib province.
The US has escalated its drone strikes on suspected al Qaeda targets in Yemen since President Abd-Rabbu Mansour Hadi took office in February 2012 after a UN-backed deal removed former President Ali Abdullah Saleh from power.