How plants identify and block invading bacteria

Washington, March 4 (ANI): A new study is trying to understand how plants defend themselves from bacterial infections, which may help scientists understand how people and other animals could be better protected from such pathogens.

The study observed a specific bacteria that infects tomatoes but normally does not bother the common laboratory plant arabidopsis.

Researchers hoped to understand how infection is selective in various organisms, according to a Texas AgriLife Research scientist.

Dr. Hisashi Koiwa collaborated with colleagues in Germany and Switzerland to examine the immune capabilities of different mutations of the arabidopsis plant.

In this study, the team was trying to figure out how a plant defends itself rather than how it gets sick, according to Koiwa, who provided about 10 different lines of mutant arabidopsis plants grown in his lab at Texas A and M University.

"By learning what is wrong with a sick plant, we can study how a plant can defend itself, what mechanisms it uses for protection," he said.

The team had to examine the plants at the cellular level where molecules are busy performing different jobs.

To understand the process, one has to examine components such as "N-glycans, receptors and ligands," Koiwa said.

The N-glycan is a polysaccharide that is critical in protein folding, a natural process which if it becomes unstable leads to various diseases, Koiwa explained.

A receptor is a protein decorated with N-glycans that awaits signals from the ligands that bind and activate receptor molecules.

In viewing this mechanism across various arabidopsis plants that had been mutated to achieve different N-glycan structures, the researchers found one particular N-glycan that was critical in making sure that the receptor molecules can recognize the targeted bacteria molecule.

If that polysaccharide can recognize a pathogen, it can prevent infection thus making the plant immune to that disease, the scientists noted.

Koiwa said many researchers are studying the pathway, or molecular road, that a pathogen takes on its journey to infect another organism.

They want to find what "gates" exist in an organism that prevent infection with the notion that the same blocks could be adapted in a susceptible organism to prevent disease.

He said eventually using this pathway to develop new plant varieties that do not allow pathogens inside the cells would be better than breeding lines that are merely "resistant" to iseases. (ANI)