The president's remarks came on a video recording that his office released. Karzai has been pushing for years to reconcile with the Taliban.
He says that effort is no longer viable since a suicide bomber claiming to be a peace emissary from the Taliban killed former Afghan President Burhanuddin Rabbani at his home on September 20. Rabbani was leading Karzai's effort to broker peace with the Taliban.
Karzai says the only way forward is for Afghanistan to negotiate with Pakistan.