Mice cages alter brains, affect scientific research

Washington, July 17 (ANI): In a breakthrough study, researchers at the University of Colorado's Anschutz Medical Campus have found that the brains of mice used in laboratories worldwide can be profoundly affected by the type of cage they are kept in.

The feat could require scientists to re-evaluate the way they conduct future experiments.

"We assume that mice used in laboratories are all the same, but they are not. When you change the cages you change the brains and that affects the outcomes of research," said Diego Restrepo, director of the Neuroscience Program and professor of cell and developmental biology.

Restrepo discovered that the brains of mice are extremely sensitive to their environment and can physically change when moved from an enclosure where air circulates freely to one where it doesn't.

Specifically, the portion of the mouse's brain responsible for its keen sense of smell, the olfactory bulb, is altered.

Restrepo also found profound changes in the levels of aggression when mice are moved from one type of cage to another.

The results can greatly affect the accuracy of the research, he said.

Two labs doing the same experiments may get totally different results and never know why.

"This could explain some of the failures to replicate findings in different laboratories and why contradictory data are published by different laboratories even when genetically identical mice are used as subjects," said Restrepo.

The consequences could mean good science derailed or promising research abandoned simply due to the design of a mouse cage - something largely overlooked until now.

He hopes scientists will work to uncover the depth of the problem and find ways to overcome it.

"We need to ensure that laboratory findings are truly indicative of natural processes and not simply the result of environmental factors within each lab," he said.

The findings of the study were just published in PLoS One, the Public Library of Science. (ANI)