Origin of HIV transmission among male partners discovered

Washington, Feb 11 (ANI): The origin of strains of human immunodeficiency virus (HIV) among men who have sex with men has been discovered by scientists.

Boffins led by a virologist from the University of California, San Diego's Center for AID Research (CFAR) made the discovery.

The study has been published in Science Translational Medicine.

"If we want to stop the HIV epidemic, then we must know the mechanisms by which HIV uses human sex to spread," said principal investigator Davey Smith, MD, MAS, associate professor of medicine in UCSD's Division of Infectious Diseases and in the Veterans Affairs San Diego Healthcare System, and director of the CFAR Viral Pathogenesis Core.

It is known that most HIV infections worldwide result from exposure to the HIV virus in semen, made up of seminal cells and the fluid around these calls, called seminal plasma. HIV virus particles contain RNA and exist in the plasma, while infected seminal cells contain HIV DNA.

Using a method of comparing genetic characteristics, called phylogenetic analysis, the researchers studied a group of men who had sexually transmitted their HIV virus to other men. Phylogenetic models allow researchers to estimate the dates of origin of various groups of viruses; in this way the team was able to determine the source of rapidly mutating HIV viruses by analyzing the viral sequences extracted from the blood and semen of HIV transmitting partners. The team found that recipients shared a more recent common ancestor with virus from the seminal plasma than with virus found in the seminal cells of their source partner.

"Until now, it had not been established whether HIV RNA or DNA is transmitted during sex," said Smith. "By analyzing the genetic differences between these two forms and the virus that was ultimately transmitted to newly infected individuals we found that it was the HIV RNA form present in seminal plasma that was transmitted."

"The findings from this study will help direct prevention strategies to address the virus in the seminal plasma," Smith said. "By knowing the origin of the transmitted virus, scientists may be able to develop new vaccines, vaginal microbicides and drugs to prevent the spread of sexually transmitted HIV." (ANI)