New target for cancer treatment discovered

Washington, Jan 12 (ANI): Scientists have identified a new way of blocking the formation of blood vessels and halt the growth of tumours using mice.

According to researchers at Karolinska Institutet, a substance that exploits this mechanism could be developed into a new treatment for cancer.

For a cancer tumour to be able to grow larger than the size of a pea, the cancer cells need to stimulate the formation of new blood vessels that can supply the tumour with oxygen and nutrients, a process known as angiogenesis.

A number of medicines which inhibit angiogenesis have been developed, but their effect has been limited, and there is still a major need for better medicines.

The new results concern a receptor on the surface of blood vessel cells called ALK1.

When the researchers blocked ALK1 in tumours in mice, angiogenesis was inhibited and the tumours stopped growing.

The ALK1 receptor is activated by a family of signalling proteins that are very important for communication between different types of cell in a wide range of key processes in the body.

The study indicates that two members of that family work together to stimulate angiogenesis in tumours.

ALK1 was blocked partly by genetic means and partly using a pharmaceutical substance called RAP-041.

"We believe that RAP-041 could be used in combination with existing angiogenesis inhibitors to achieve the maximum effect," said associate professor Kristian Pietras, who led the study. (ANI)