Arthritis wonder drugs may hold key for many more diseases

Washington, July 18 : Drugs that can help treat rheumatoid arthritis may hold the key to many more medical conditions, including atherosclerosis, say a group of researchers.

Atherosclerosis is a disease affecting arterial blood vessels that leads to heart disease.

Professor Marc Feldmann will tell scientists attending the 2008 Congress of European Pharmacological Societies (EPHAR) - hosted by the British Pharmacological Society - that drugs he and colleagues helped develop have already proved successful against other autoimmune diseases.

The drugs target proteins called cytokines, which are protein messaging molecules released by immune cells to alert the immune and other systems that the body is under attack from a pathogen and to initiate a protective counter-response against the infection.

"In autoimmune diseases, such as arthritis, we discovered that cytokines are over-produced causing the immune system to fight itself, resulting in inflammation and tissue destruction," said Professor Feldmann, from Imperial College London, who is speaking at the EPHAR 2008 conference at The University of Manchester this week.

"We further found that by blocking just one cytokine - Tumor Necrosis Factor (TNF) alpha - we were able to block all the cytokines involved in the inflammation, with remarkable clinical results," he added.

The research led to the development of three anti-TNF alpha drugs - infliximab, etanercept and adalimumab - which have had a dramatic effect on the symptoms of rheumatoid arthritis patients, protecting the joints from further deterioration in the vast majority of cases.

Blocking TNF alpha has had further success in treating several more chronic inflammatory conditions, including Crohn's disease, psoriasis, psoriatic arthritis, ankylosing spondylitis and ulcerative colitis.

But Professor Feldmann, Head of the Kennedy Institute of Rheumatology, believes similar drugs have the potential to treat many other medical conditions and will also tell the conference about his work on atherosclerosis, a disease affecting the arterial blood vessels, commonly known as 'hardening of the arteries', with his colleague Dr Claudia Monaco.

ANI