• search
For Quick Alerts
For Daily Alerts

Now, 'DNA patches' to treat canine form of muscular dystrophy

By Super Admin

Washington, Mar 17 (ANI): Researchers have developed a new technique in which DNA patches are used to treat dogs with the canine version of Duchenne muscular dystrophy, a paralysing and often fatal disease of muscles.

Called "exon skipping", the technique uses tailor-made snippets of DNA-like molecules as molecular "patches", which cover up mutant DNA sequences that code for making an important muscle protein.

The mutant sequences occur in portions of the gene known as exons, which contain the information needed to make the muscle protein.

By covering up the mutant regions, the DNA patches allowed the dogs to make an imperfect-but functional-version of the protein, and significantly improve their muscle functioning.

The researchers say that their findings have shown that the DNA patches could be delivered by injection throughout the entire body in a much larger animal than a mouse, raising the possibility that they might be successfully delivered into the human body as well.

The current study also represents an advance over the earlier efforts in that it was able to use several different kinds of DNA patches.

A combination of different patches, known as a cocktail, would be needed to treat most of the human cases of the disease, which can involve many different exons.

The canine version of Duchenne muscular dystrophy occurs naturally in dogs, and affects the same gene that is affected in the human form of the disease.

"This is a promising finding. It's an important step toward realizing the goal of developing a treatment that could alleviate the symptoms of this disorder," said Dr. Duane Alexander, director of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).

The study was published online in the Annals of Neurology. (ANI)

For Daily Alerts
Get Instant News Updates
Notification Settings X
Time Settings
Clear Notification X
Do you want to clear all the notifications from your inbox?
Settings X
We use cookies to ensure that we give you the best experience on our website. This includes cookies from third party social media websites and ad networks. Such third party cookies may track your use on Oneindia sites for better rendering. Our partners use cookies to ensure we show you advertising that is relevant to you. If you continue without changing your settings, we'll assume that you are happy to receive all cookies on Oneindia website. However, you can change your cookie settings at any time. Learn more