• search
For Quick Alerts
For Daily Alerts

Vascular drug improves learning and memory in rats

By Super Admin

Washington, Feb 2 (ANI): Arizona researchers have revealed that a drug, which is used to treat vascular problems in brain, can effectively improve learning and memory.

The drug known as Fasudil, which has been used for more than 10 years to treat vascular problems in the brain, often helping with recovery from stroke, has been found to improve cognition in middle age rats.

However, further studies are required to prove its efficacy in humans.

During the study, the researchers injected hydroxyfasudil, the active form of Fasudil, into middle-aged (17-18 months old) male rats daily starting four days before behavioural testing and continuing throughout testing.

The rats were tested on the water radial-arm maze, which assessed how well they remembered which of the radiating arms had a reward, a sign of accurate spatial learning and working memory.

The team found that rats given a higher dose successfully remembered more items of information than those given a low dose.

Moreover, the high-dose group showed the best learning (and best working memory.

The findings suggest that hydroxyfasudil may be involved in two crucial cognitive processes, learning and working memory, both involving the hippocampus.

Although the mechanism is unclear, but hydroxyfasudil's parent drug, Fasudil, is known to protect the brain by dilating blood vessels when blood flow is curtailed.

"We have identified a drug that seems to benefit both the cardiovascular system, which it was originally designed to do, and the central nervous system, a new indication," said lead author Dr. Matthew Huentelman.

"We are actively exploring options for a clinical trial in the areas of cognitive impairment and dementia using the well-tolerated pro-drug Fasudil," he added.

The finding appears in the journal Behavioral Neuroscience. (ANI)

For Daily Alerts
Get Instant News Updates
Notification Settings X
Time Settings
Clear Notification X
Do you want to clear all the notifications from your inbox?
Settings X
We use cookies to ensure that we give you the best experience on our website. This includes cookies from third party social media websites and ad networks. Such third party cookies may track your use on Oneindia sites for better rendering. Our partners use cookies to ensure we show you advertising that is relevant to you. If you continue without changing your settings, we'll assume that you are happy to receive all cookies on Oneindia website. However, you can change your cookie settings at any time. Learn more