Manmohan Singh was received by White House chief of protocol Capricia Marshall at Andrews Air Force base. India's ambassador to the US Meera Shankar was also present to welcome the Prime Minister.
According to reports, Singh will have a packed schedule of bilateral meetings with the leaders of the US, France and Canada.
However, there is no sign of any bilateral meeting between Manmohan Singh and Pakistan Prime Minister Yousaf Raza Gilani who has also been invited for the summit.
In their first bilateral meeting since Obama hosted maiden state dinner of his administration for Manmohan Singh in Nov 2009, the two leaders are set to discuss a cluster of issues that are of pressing concern to them.
India will raise concerns about the possibility of terrorists gaining access to nuclear material in Pakistan.
Ahead of the meeting between Manmohan Singh and Barack Obama during which Afghanistan will figure, sources said India's policy on Afghanistan will be determined by its own interests and not by what others do.
Sources also said that Manmohan Singh is expected to raise the issue of terror suspect David Colemen Headley's direct access to India.
India has been pitching for full access to Headley, an American-Pakistani LeT operative who has confessed to his role in plotting the 26/11 attacks, but the US has cited intricate legal procedures, saying it has yet to make a decision on it.