America's Harvard University holds the top position in 2009 while UK's Cambridge University secured the second position. while Yale University of US slipped one position to third.
QS/Times Higher Education rankings showed the University College London (UCL) beat Oxford University which, slipped from fourth to joint fifth position along with Imperial College, London.
The report showed that UK still heads the list with four out of the top 10 slots and 18 in the top 100.
The number of Asian universities in the list of top 100 increased from 14 to 16.
The University of Tokyo, at 22, is the highest ranked Asian university, ahead of the University of Hong Kong at 24.