The mission will begin its eight-year journey to Jupiter and its moons.
The mission was scheduled to take off on Thursday but was delayed due to bad weather.
Led by the European Space Agency (ESA), the mission will orbit the largest planet in the solar system and explore its icy moons.
JUICE will explore three possible ocean-bearing moons – Europa, Ganymede and Callisto.
Under their icy surfaces are thought to be huge oceans of water – a crucial ingredient for life as we know it.
Why is a mission to Jupiter important? There is hope Jupiter’s icy moons will have some kind of living organisms, said Carole Larigauderie, JUICE project head.