Double vaccinated against Covid first, experts say amid calls for booster shots
New Delhi, Dec 04: India should prioritise double vaccinating its eligible population against Covid over booster shots given the large number of people still to get the base layer of protection against the infection, say scientists.
Concerns over the Omicron variant and waning vaccine-induced protection against the infection have highlighted the need for boosters to protect the most vulnerable. And while many countries have already started giving booster shots, several experts here said the priority in India has to be different given that large-scale immunisation programme began only six-eight months go. In advocating putting boosters on the back-burner for the moment, the experts' opinion runs counter to the Indian SARS-CoV-2 Genomics Sequencing Consortium (INSACOG) that has recommended a booster dose for those above 40 years in high-risk and high-exposure populations.
The INSACOG is a network of national testing labs set up by the government to monitor genomic variations of COVID-19.
"We have a large proportion of our population in the below 18 age-group. Until that is achieved, a uniform policy for second booster, or a third dose, is not advisable," immunologist Vineeta Bal told PTI, pointing out that large-scale vaccination in India began only in March 2021.
What we should focus on, she said, is fully vaccinating all the eligible population in India and pushing for vaccination of the under 18 age group on a large scale.
"Consistent finding with breakthrough infections is that these episodes are less in severity as compared to unvaccinated. That still confirms that immunity does exist in vaccinated individuals in India," Bal, guest faculty at Pune's Indian Institute of Science Education and Research, told PTI.
Satyajit Rath, from New Delhi's National Institute of Immunology (NII), added that it is not clear yet if boosters are needed for any vaccine worldwide yet.
"The
duration
of
immune
responses
and
protection
are
beginning
to
show
differences,
too,
in
recent
studies.
So
I
would
be
loath
to
jump
the
gun
and
say
anything
very
definitive
about
boosters
based
on
these
data,"
he
told
PTI.
Bal
agreed
that
there
is
no
solid
data
on
waning
immunity
in
India.
In
principle,
of
course,
immunity
will
wane
with
time.
"Antibody levels in serum will be lower six months down the road than soon after vaccination but that is not the only and adequate evidence of significant lowering of protective immunity which is based on immunological memory," she added.
Vasant Nagvekar, a consultant on infectious diseases at a Mumbai-based hospital and a member of the Maharashtra government's COVID-19 task force on Thursday, said a booster dose of vaccine, even if it works, is just a temporary fix and the emphasis should instead be on mask use.
''Scientific data has proven that masks can reduce COVID-91 transmission by 53 per cent...A booster dose of vaccine, even if it works, is just a temporary fix. We can't keep on taking boosters every six months and for every variant of concern that emerges. Masking is the need of the hour and there is no Alternative for vaccination,'' he said in a statement.
"What we should have been doing, and maybe should still be doing, is providing better and better masks, reusable and biodegradable, freely and widely accessible on a large scale, and to build a community-driven programme and campaign for cultural adoption of covid-appropriate behaviour." "That will quite likely be reasonably effective against future variants too," the scientist added.
Pune-based Serum Institute of India, which manufactures Covishield, on Thursday sought approval from India's drug regulator for a booster dose, citing adequate stock of the vaccine in the country and a demand for a third shot due to the emergence of new coronavirus variants.
The
government
in
a
press
briefing
has
said
scientific
reasoning
for
booster
vaccine
doses
for
COVID-19
is
under
examination
but
the
priority
is
to
ensure
complete
vaccination
of
the
eligible
population
with
both
doses.
Kerala,
Rajasthan,
Karnataka
and
Chhattisgarh
have
urged
the
Centre
to
decide
on
allowing
booster
doses
of
the
Covid
vaccine
diseased
amid
Omicron
concerns.
In
Bal's
view,
fully
vaccinated
individuals
still
show
protection
and
nobody
knows
whether
the
Omicron
variant
will
spread
as
rapidly
as
Delta
did
earlier
and
whether
it
will
be
more
or
less
transmissible
than
Delta.
''At
individual
levels,
booster
doses
would
result
in
boosting
pre-existing
response
further,
and
this
will
certainly
be
useful,
in
principle,"
she
said.
"However, current vaccines will still use the old reference strain-based vaccine, hence neither Delta-specific nor Omicron-specific boosting can be achieved by a booster dose," Bal added.
Bal said the virus will continue to mutate, more so since a huge number of individuals in lower-middle-income countries (LMICs) and also in developed countries remain unvaccinated.
"Concentrating efforts on newer and newer variants for vaccine development does not appear practical," she added.
Rath said while booster doses may provide some increase in antibody levels, how long that extra protection lasts is not known.
"Will that increase, as long as it lasts, contribute to some better protection against virus spread? Yes, but it will quite likely not be a very large effect. Will boosters of the current vaccines protect against future variants? The answer is, who knows?" the scientist added.
At least 36 countries are administering booster doses of the Covid vaccine, according to Our World in Data. However, the WHO wants the most vulnerable people worldwide to be fully vaccinated first.
According
to
a
study
in
The
Lancet,
six
different
COVID-19
boosters
are
safe
and
provoke
a
strong
immune
response
in
people
who
have
previously
received
a
two-dose
course
of
AstraZeneca
or
Pfizer
vaccines.
The
vaccines
studied
were
AstraZeneca,
Pfizer-BioNTech,
Novavax,
Janssen,
Moderna,
Valneva,
and
Curevac.
"The side effect data show all seven vaccines are safe to use as 3rd doses, with acceptable levels of inflammatory side effects like injection site pain, muscle soreness, fatigue," said Prof Saul Faust, trial lead from the University Hospital Southampton NHS Foundation Trust, UK.
Bal noted that boosters have more benefit psychologically than in terms of providing further protection, for common people, excluding vulnerable populations. ''However, vaccinating people from the global south is very critical at this point. We have seen how rapidly Omicron crossed national and continental barriers to reach different parts of the globe.
"Unless pretty much everybody is vaccinated globally there is no way of sitting back, the immunologist added.
India has administered 1,26,37,79,602 (126 crore/1.26 billion) vaccine doses so far, with 79,68,96,038 (79.6 crore/796 million) receiving one dose while 46,68,83,564 (466 million/ 46.6 crore ) receiving two doses.