• search
For Quick Alerts
ALLOW NOTIFICATIONS  
For Daily Alerts

Now, a one-two drug punch approach to KO a lethal cancer

By Super Admin
|

London, June 8 (ANI): Researchers have found that a two-drug combination of Zileuton and Gleevec could be a potent treatment of a lethal cancer, called chronic myeloid leukemia (CML).

Dr, Shaoguang Li, The Jackson Laboratory Adjunct Professor, led a team of researchers who identified a gene, called Alox5, involved with the inflammatory response that could hold the key to treating or even preventing CML.

The researchers also showed that an asthma medication for human patients was an effective treatment for CML in mice, reports Nature magazine.

Alox5 processes essential fatty acids to leukotrienes, which are important agents in the inflammatory response.

However, the researchers believe that Alox5 has a more sinister side-it is vital to the development and maintenance of cancer stem cells.

They say that cancer stem cells must be targeted for effective treatment of many cancers, but direct evidence is still lacking.

In the new study, the researchers found that CML did not develop in mice without Alox5 because of impaired function of leukemia stem cells.

Furthermore, Alox5 deficiency did not affect normal stem cell function, providing the first clear differentiation between normal and cancer stem cells.

The researchers also treated mice with CML with Zileuton- an asthma medication that inhibits the Alox5 inflammation pathway, as well imatinib-commonly known as Gleevec, the most effective current leukemia medication.

They found that imatinib effectively treated CML, but Zileuton was more effective. The two drugs combined provided an even better therapeutic effect.

The researchers are now seeking patent protection on the novel approach to treat CML that Li and colleagues have demonstrated.

The findings reveal how leukaemia stem cells are distinct from normal stem cells and how they can be targeted in cancer therapies.

The study has been published in the journal Nature Genetics. (ANI)

For Daily Alerts
Get Instant News Updates
Enable
x
Notification Settings X
Time Settings
Done
Clear Notification X
Do you want to clear all the notifications from your inbox?
Settings X
X
We use cookies to ensure that we give you the best experience on our website. This includes cookies from third party social media websites and ad networks. Such third party cookies may track your use on Oneindia sites for better rendering. Our partners use cookies to ensure we show you advertising that is relevant to you. If you continue without changing your settings, we'll assume that you are happy to receive all cookies on Oneindia website. However, you can change your cookie settings at any time. Learn more