Sania and Cara suffered a 2-6, 4-6 loss in an hour and 10 minutes to the unseeded team at the Louis Armstrong here Thursday.
Last year as well, Sania, who was partnering China's Jie Zheng then, failed to get past the semis stage.
But the Indian tennis star still has a shot at the top prize. Sania and her Brazilian partner Bruno Soares, the top seeds, will take on American-Mexican team of Abigail Spears and Santiago Gonzalez in the final of the mixed event.
Sania is the only Indian left in the competition after Leander Paes and Rohan Bopanna bowed out from their respective doubles events in the earlier rounds.