Though Olympic bronze medallist Saina came out on top, P.V. Sindhu, Kidambi Srikanth and Parupalli Kashyap went out of competition at the Istora Gelora Bung Karno Stadium.
A three-time winner here, Saina needed only 33 minutes to ease past Thailand's Porntip Buranaprasertsuk 21-15, 21-10 to take an amazing 7-1 lead in career meetings over the World No.9.
The eighth seed will in the women's singles second round meet Scottish Kirsty Gilmour against whom Saina has an unbeaten 2-0 head-to-head.
P.V. Sindhu, Kidambi Srikanth and Parupalli Kashyap went out of competition
Later, Sindhu's match didn't turn out as she had expected. The World No.10 Hyderabadi gave a good fight to China's third seed Yihan Wang by taking the first game a long way before losing out 24-26. Sindhu fought brilliantly but ran out of steam to lose the second game too to the former World Champion 17-21.
In men's singles action, China's Chen Yuekun beat Srikanth 21-12, 17-21, 21-16 in 55 minutes while Japanese fourth seed Kenichi Tago ousted Parupalli Kashyap 19-21, 21-8, 24-22 in an hour and nine minutes.
Jwala Gutta and Ashwini Ponnappa will take on Indonesians Pia Zebadiah Bernadeth and Rizki Amelia Pradipta in the women's doubles opener later in the day.