The Argentine scored a hat-trick for Barcelona against Sevilla (November 22) to become the all-time highest goalscorer in Spanish league history.
"He's a unique player - there'll never be anyone like him and we're lucky to enjoy his presence here," Barcelona coach Luis Enrique said of Messi.
"I think he will leave the record unreachable for anyone else," he added.
Messi now has 253 goals from 288 games. He erased a 59-year-old record. The previous mark was held by Telmo Zarra, with 251 goals since 1955. Zarra played for Athletic Bilbao.
At the age of 13, Messi joined the Barcelona academy. He made his La Liga debut in 2004-05 season and has taken 10 seasons to break the top goalscorer record.
Messi has several records in his CV and is set to add many more considering he is still 27.
Here is the full list of Lionel Messi's records (as on November 23, 2014)
- La Liga top scorer: 253 (288 games)
- Barcelona's top goalscorer: 368
- Champions League top scorer: 71 (joint with Raul)
- Most goals in a La Liga season: 50
- Most goals in a season: 68
- Most consecutive La Liga matches scored in: 21
- Most FIFA Ballon d'Or Awards (Best Player): 4 (2010-13)
- Most goals in a single European Cup game: 5 (joint with Luiz Adriano)
- Most European Cup top scorer awards: 4 (with Gerd Muller)
- Most goals in El Clasicos: 21
- Most La Liga hat-tricks in a season: 8 (2004-05)
- Most goals in Club World Cup: 4 (held jointly with Denilson)
- Most goals in a calendar year: 91 (Year 2012)