Real Madrid have a 3-1 lead over Napoli from the first leg and have their one foot in the next round as Napoli will have to win 2-0 or more to go through.
Bayern Munich, on the other hand, has a comfortable 5-1 lead on aggregate from the first leg over Arsenal. The Bavarian giants had thrashed the Gunners at home.
It looks practically impossible Arsene Wenger's side to overturn their fortune at the Emirates stadium.
On Thursday, March 9, Borussia Dortmund face Benfica, while FC Barcelona take on Paris Saint-Germain at the Camp Nou stadium.
Benfica travels to Germany with a 1-0 lead on aggregate. Paris Saint-Germain, on the other hand, have a 4-0 lead over the Catalan giants.
It was one of the most embarrassing Barcelona had suffered in a long time. It looks virtually impossible for them to qualify for the next stage.
Here are all the matches from Champions League round of 16 second leg, game week 1:
Wednesday, March 8
Napoli Vs Real Madrid - 1:15 AM (IST)
Arsenal Vs Bayern Munich - 1:15 AM (IST)
Thursday, March 9
Borussia Dortmund Vs Benfica - 1:15 AM (IST)
FC Barcelona Vs Paris Saint-Germain - 1:15 AM (IST)