Reigning champions and league giants FC Barcelona take on Leganes. It will be a really crucial encounter for Luis Enrique's men who had encountered a shocking defeat against minnows Alaves.
In another game on Saturday, Diego Simeone's Atletico Madrid take on Sporting Gijon. Atletico finally gained some momentum last week by beating Celta Vigo 4-0. Their start to the season was horrible as they lost and drew the first two games.
On Sunday midnight, Real Madrid take a trip to Catalunya to face Espanyol. Zinedine Zidane's men are at the top of the table now with full 9 points from the first three matches.
With Cristiano Ronaldo back in the team, the squad has become stronger than ever. The Los Blancos will eye full 3 points to extend their lead in the league.
Here is the full schedule of game week 4 of La Liga:
September 17 (Saturday) - Real Betis Vs Granada - 12:15 AM (IST)
September 17 (Saturday) - Leganes Vs FC Barcelona - 4:30 PM (IST)
September 17 (Saturday) - Atletico Madrid Vs Sporting Gijon - 7:45 PM (IST)
September 17 (Saturday) - Eibar Vs Sevilla - 10:00 PM (IST)
September 18 (Sunday) - Las Palmas Vs Malaga - 12:15 AM (IST)
September 18 (Sunday) - Osasuna Vs Celta Vigo - 3:30 PM (IST)
September 18 (Sunday) - Atheltic Bilbao Vs Valencia - 7:45 PM (IST)
September 18 (Sunday) - Villarreal Vs Real Sociedad - 10:00 PM (IST)
September 19 (Monday) - Espanyol Vs Real Madrid - 12:15 AM (IST)
September 20 (Tuesday) - Alaves Vs Deportivo - 12:15 AM (IST)