The presence of longtime foes Jose Mourinho and Arsene Wenger at the dugout will add extra spice to this crucial encounter.
It is a known fact that Mourinho and Wenger are not particularly fond of each other. Since his days at Chelsea FC, Jose have been critical of Wenger's managerial outlook and have often publicly criticised him for failing continuously. The famous 'Specialist in failure' jibe is still fresh in every football fan's mind.
Wenger too has often lost his cool over the Portuguese and he even had on-field physical altercation during a Chelsea Vs Arsenal game in 2014.
Overall Jose Mourinho enjoys a better head to head record against Arsene Wenger.
Manchester United will miss the services of several important first team players. Star striker Zlatan Ibrahimovic is suspended due to double booking.
Defenders Eric Bailly and Chris Smalling have been ruled out of the game due to injuries. Antonio Valencia is also doubtful.
Mourinho may field Marcus Rashford in the front striker position. Anthony Martial, Juan Mata and Paul Pogba will compose the attacking midfield.
Marouane Fellaini is likely to start alongside Ander Herrera who will be back in the squad after serving a one-match ban.
Arsenal have only one injury concern. Spanish right-back Hector Bellerin has been ruled out of the match owing to a severe knee injury. Bellerin is out of action for almost a month. Carl Jenkinson is likely to replace the Spaniard.
Alexis Sanchez who had picked up a hamstring injury while playing for Chile last week, has confirmed his presence for the match. The star attacker played for Chile in their latest clash against Uruguay and scored two goals.
Manchester United (4-2-3-1)
Goalkeeper: David De Gea
Defenders: Antonio Valencia, Phil Jones, Marcos Rojo, Daley Blind
Midfielders: Marouane Fellaini, Ander Herrera; Juan Mata, Paul Pogba, Anthony Martial
Striker: Marcus Rashford
Arsenal FC (4-2-3-1)
Goalkeeper: Petr Cech
Defenders: Carl Jenkinson, Shkodran Mustafi, Laurent Koscielny, Nacho Monreal
Midfielders: Granit Xhaka, Francis Coquelin; Alex Iwobi, Mesut Ozil, Theo Walcott
Striker: Alexis Sanchez
Manchester United 0-2 Arsenal FC