Antonio Conte's Chelsea are comfortably placed at the top of the table with lead of 9 points over second and third-placed Tottenham Hotspur and Arsenal who are on 47 points from 23 matches.
It is a must win game for Arsene Wenger's Arsenal as another defeat or draw will put Chelsea beyond their reach and the Gunners will slowly drift away from the title race.
Kick-off: 6:00 PM (IST)
Venue: Stamford Bridge, Chelsea
Match will be telecasted LIVE on Star Networks and Hotstar.
Arsenal will miss the services of Aaron Ramsey, Granit Xhaka and Santi Cazorla. While Cazorla and Ramsey are out wth injuries, Xhaka is out due to a red card he had conceded last to last game week.
Ramsey received a knock this midweek against Watford which Arsenal lost 1-2. Mohammed ElNeny is likely to fill in for Ramsey in central midfield and pair up with Francis Coquelin.
Rest of the side will remain the same with Olivier Giroud starting as front striker supported by Alexis Sanchez, Mesut Ozil and Alex Iwobi in the attacking third.
Antonio Conte, on the other hand, might make one change in the starting which drew against Liverpool midweek. Pedro might come into the starting XI replacing Willian.
Goalkeeper: Thibaut Courtois
Defenders: Cesar Azpilicueta, David Luiz, Gary Cahill
Midfielders: Victor Moses, N'Golo Kante, Nemanja Matic, Marcos Alonso
Strikers: Eden Hazard, Diego Costa, Pedro
Goalkeeper: Petr Cech
Defenders: Hector Bellerin, Shkodran Mustafi, Laurent Koscielny, Nacho Monreal
Midfielders: Mohammed Elneny, Francis Coquelin; Alex Iwobi, Mesut Ozil, Alexis Sanchez
Striker: Olivier Giroud
Chelsea 2-1 Arsenal