Gayle came into the match with just 3 runs needed to complete the feat and he did it in the fourth over of the match off Gujarat Lions' Basil Thampi's delivery.
Gayle was dismissed in the 13th over after he scored 77 runs off just 38 balls. He along with captain Virat Kohli guided RCB's score to 213 runs in 20 overs.
The West Indian did not start the tournament on a high this season, as he managed to score only 60 runs in the first three matches.
He was also dropped from the starting XI against Rising Pune Supergiant, which they lost due to poor form. But the man came back strongly and played a brilliant knock.
As Gayle creates the world record, fans and celebrities around the world took Twitter to congratulate him.
Here are the reactions on Twitter
David Warner praised Gayle
Sunrisers Hyderabad captain hailed Chris Gayle for completing 10,000 runs in T20.
Harsha Bhogle praised 'boss' Gayle
Harsha Bhogle praised Chris Gayle for completing 10,000 T20 runs and called him the boss of the game.
Michael Clarke congratulates Gayle
Former Australian captain Michael congratulated Chris Gayle for completing 10,000 T20 runs.
RCB's unique way to congratulate Gayle
Royal Challengers Bangalore (RCB) congratulated Chris Gayle for completing 10,000 runs.
Yohan Blake praised Chris Gayle
Sprinter Yohan Blake pointed why RCB were wrong to drop Chris Gayle in the previous match.
Chris Gayle's amazing stats in T20
Chris Gayle has scored 7530 runs just in boundaries!
Chris Gayle's 10,000 runs in T20
A details list of runs scored by Chris Gayle in T20 cricket.
Gayle hailed as "GODZILLA of Cricket"
Fans hailed Chris Gayle as the"GODZILLA of Cricket".
'World Boss' Chris Gayle
Fans hail 'World Boss' Chris Gayle