The 27-year-old led four others through the line in sub-10 second times at the Roi Baudouin Stadium in the Belgian capital Friday, reports CMC.
"it's my last race of the season and I'm happy," said Bolt.
American Michael Rodgers claimed second place in a season's best of 9.90sec, with Jamaica's Nesta Carter nipping world silver medallist Justin Gatlin for third after both were clocked at 9.94.
"It's my last race of the season, the time's close to my season's best (of 9.77 seconds), I'm happy," said Bolt.
"This was close to the 'Usain Bolt fashion', not only because this was the last race of the season but also because of the crowd."