Bindra shot 208.8 points to clinch the gold while compatriots Gagan Narang and Chain Singh finished fourth and sixth respectively at the Dr Karni Singh Shooting Range.
All the three shooters have already secured quota places for next year's Olympics to be held in Rio de Janeiro.
Apurvi Chandela will be seen in action in the women's 10m air rifle event on Monday. The Commonwealth medallist has also booked her place at the Rio Olympics.
This is the first international shooting competition to be held in India after a gap of almost five years, the last being the Delhi Commonwealth Games in 2010.