Wawrinka and France's Tsonga, who have been at odds in the past, argued heatedly at the first-set changeover and there was no love lost as the Swiss charged to a 7-6 (7/2), 6-4, 6-3 win.
On beating Tsonga, Wawrinka said: "It's not easy to play against him, he's a strong player. In the semis I play Roger. It's going to be tough to have some fans but I hope some people will cheer for me."
It puts 2014 champion Wawrinka, 31, into his third Melbourne semi-final where he will play compatriot and ever-popular Roger Federer.
The former world number 1 defeated Germany's Mischa Zverev 6-1 7-5 6-2 to qualify for the semi-final. It was an easy game for Federer as Zverev proved to be no match for the Swiss maestro.
Roger's post match interview is given below: