"Any death of this sort is a tragedy. Any shooting involving multiple victims is a tragedy," the president said at the White House.
"There is something particularly heart breaking about a death happening in a place in which we seek solace and we seek peace, in a place of worship."
The shooting took place at the Emanuel African Methodist Episcopal Church on Wednesday.
Read More: Charleston shooting: Suspect under arrest
The 21-year-old white man Dylann Storm Roof has been identified as the suspected gunman that opened fire inside the Emanuel African Methodist Episcopal (AME) church Wednesday night is now in police custody.