The shooting took place at the Emanuel African Methodist Episcopal Church on Wednesday. The shooter is still at large, CNN reported.
According to reports nine people have been killed in the shooting at the church. Number of casualties is yet to be confirmed.
"It's really bad. It's a very bad scene," local pastor Thomas Dixon said.
Manhunt has been launched to nab the suspect in his mid 20s.
Police said the suspect in the shooting is a clean-shaven white man in his 20s, with a slender build. He was wearing a gray sweatshirt, blue jeans and boots.