Implementation of the US plan would undermine Russia's security and force Moscow to undertake corresponding measures to tackle that threat, Xinhua quoted Grushko as saying on Monday at a security conference held here.
"The US ignores the interests of regional security," he said, without elaborating on the measures.
A new American military base in Deveselu, Romania is due to be set up and running next year as a part of NATO's overall ballistic missile defence system, a US Department of the Navy statement said Saturday.
According to the US plan, Deveselu will host a land-based SM- 3 ballistic missile defense interceptor site and the facility is scheduled to be operational starting in 2015.
Grushko also said the project of European integration has failed due to "highly dangerous" western policy of deepening divisions between Europe and Russia.