The Syrian Observatory for Human Rights reported massive bombardment across the eastern side of the battered city, five days into a renewed government assault on opposition-held districts.
"There's barely a neighbourhood that has been spared in the east," said Observatory director Rami Abdel Rahman.
The deaths brought the civilian toll in five days of regime bombardment of eastern Aleppo to at least 92, according to the Observatory which said however that many of the wounded were in serious condition.
Aleppo has been divided since mid-2012 between rebel control in the east and government control in the west, and the opposition side has been surrounded by the regime for nearly four months.
The siege has created food and fuel shortages in the east, and the renewed bombardment has damaged or destroyed multiple medical and rescue worker facilities.