The Beechcraft BE36 aircraft crashed into the house while flying from Lancaster Airport in Pennsylvania to Norwood Memorial Airport in Massachusetts on Sunday.
"The crash happened at about 5:45 p.m. Sunday," Jim Peters of the Federal Aviation Administration was quoted as saying by media.
Fire tenders took nearly three hours to douse the flame. None of the housemate were killed as they managed to escape the house.
The plane wound up behind the two-story colonial, where a section of the tail and a charred wing rested on a hillside in the yard.
Neighbors reported hearing something amiss as the plane flew over their homes.
The National Transportation Safety Board (NTSB) is expected to arrive at the crash site on Monday.
The identities of the victims are yet to be released.