According to reports, a gas cylinder installed in a vehicle exploded when a motorcycle carrying explosives collided with it at Vehari Chowk in Multan on Sunday evening.
Many shops, buses and other vehicles in the area damaged due to the strong intensity blast, The Express Tribune reported.
No group has claimed responsibility for the attack.
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The death toll is likely to go up because of the serious nature of some of the injuries.
Pakistan's Prime Minister Nawaz Sharif has expressed his condemnation and sorrow over the Multan explosion.