Speaking from Yosemite National Park in California on Saturday, one of the most popular natural sanctuaries, Obama said that climate change is the "greatest challenge" facing nature reserves, EFE news reported.
"Make no mistake, climate change is no longer just a threat, it is a reality," said Obama from the Sentinel Bridge, which faces one of the highest waterfalls in the world, Lower Yosemite Falls, with a drop of 740 metres.
"Here in Yosemite, streams are drying up, the birds are moving north, alpine mammals are moving up to escape the high temperatures. The largest glacier in Yosemite has now almost disappeared," he added.
Obama also recalled that fire seasons were becoming longer and more expensive while rising sea levels could one day destroy the Everglades National Park in Florida or "even threaten" the Statue of Liberty in New York.
"The idea that these places that remain engraved in our memories may be damaged or lost forever, is something to take seriously," he said.
According to the White House in 2015, more than 305 million people visited national parks in the country, with some $16.9 million going to local communities in tourist revenues.
On Friday, Obama and his family also visited Carlsbad Caverns national park in New Mexico.
To commemorate the centenary of the creation of the National Park Service, a ceremony that will be held this August, Obama has also participated in recording a National Geographic virtual reality video.
He is the first American president to make such a tribute to the ceremony, according to the White House.