The incident took place at Ramechhap district on late Friday when the bus was heading towards Gothagaon VDC from the district headquarters Manthali, Himalayan Times reported.
The bus was reportedly carrying 52 passengers at the time of accident. The reason behind the mishap is yet to be known, police said.
According to preliminary reports, bus driver is solely responsible for the mishap.
The injured people have been admitted at the nearby hospitals.