The official confirmation of his death is yet to be announced. Hussain who adopted the nom de guerre Abu Hussain al-Britani, had been a key figure within so called "Cyber Caliphate" of ISIS.
The Birmingham-born Junaid Hussain travelled to Syria in 2013 and is considered the most prominent UK citizen to have joined ISIS, The Guardian reported.
The strike is believed to be a US military operation, rather than a CIA drone attack.
Hussain is also considered as the man who played vital role in obtaining the passwords of the US Central Command's Twitter and YouTube accounts in January and briefly using them to send pro-Isis messages.
In Britain, the 21-year old Hussain had been part of the hacker group Team Poison, where, using the handle Trick, he gained access to the address book of former Prime Minister Tony Blair and published information from it. The hack earned him six months in jail in 2012.