"I wish to make it known that I have ended my common life with Valerie Trierweiler," Hollande told AFP, Xinhua reported.
The breakup came after a local celebrity magazine Closer reported on the president's secrete love affair with a French actress Julie Gayet.
Trierweiler has been Hollande's partner since 2006.
The 48-old-year journalist was hospitalised as she suffered from "an extreme nervous exhaustion", a week after the publication of a seven-page photo spread, titled "the President's secret love."
Trierweiler has been Hollande's partner since 2006. They were not married but she assumed the role of First Lady at official ceremonies and state visits.
As questions have been raised on his presumed affair with Gayet, the Socialist head of state has neither confirmed nor denied the reports, urging a respect of his private life.