The US unmanned plane fired two missiles at a compound in the Ghulam Khan area of North Waziristan, a restive tribal region bordering Afghanistan, Xinhua reported citing media reports quoting official sources.
Ghulam Khan is also the third most important border crossing point between the two countries after Chaman and Torkham.
The missiles completely destroyed the building and killed four people inside. Locals rushed to site and took out the bodies from the rubble of the building.
There were no reports yet about the identities of the people who were killed.
Thursday night's attack in North Waziristan is the 19th of its kind in Pakistan since the start of this year that is said to have killed at least 120 people so far.