Panic has struck west Africa mainly Sierra Leone, Liberia as hundreds have already died due to the disease.
A specially equipped medical charter flight left the US to bring back the two citizens who have contracted the virus.
Doctors say that the US citizens will have to be in sa sanitized environment before being given any treatment.
Meanwhile, Ebola virus that is spread through an infected person's body fluids, has already killed hundreds in S Africa. The disease has a lethal morality rate and is originally thought to have come from infected monkeys and bats.