The five new cases included two in Zhejiang, two in Guangdong and one in Fujian, according to the health and family planning commissions in the three provinces, Xinhua reported.
The patient who died in Fujian was confirmed early on Friday to have been infected with the virus, and died in the hospital the same morning.
The two cases in Zhejiang, a 79-year-old woman and a 30-year-old man, were both in critical condition.
Two mild cases, a 42-year-old woman and a 59-year-old woman, were also reported on Friday in Guangdong, where a total of 12 cases have been confirmed since last August.
Human cases of the bird flu virus have also been reported in the provinces of Zhejiang, Jiangsu and Guangdong so far this year.