"Whenever I had trouble, she was a rock in our family," he said opening up about his relationship with Hillary in an interview with CNN set to air on Sunday.
"I trust her with my life, and have on more than one occasion," Clinton said, describing his wife as someone who helped him through some of the most trying times of his life.
Clinton described how his wife helped him through years "plagued with self-doubt" in his late 20s and offered him someone to not only lean on, but to help guide him through perilous moments in his career.
"I was the youngest former governor in American history in 1980 on election night. I got killed in the Reagan landslide," Clinton remembered.
"People I had appointed to office would walk across the street, they were so afraid of the new regime in Arkansas, and would not shake hands with me. My career prospects were not particularly bright."
"And she never blinked. She just said, 'Hey. It'll turn around. I believe in you. You've got this'," he was quoted as saying.
Reflecting on their 40 years of marriage since 1975 after meeting at Yale University, Clinton said: "We built a life together based on the things we cared about, the things that we loved."
"We were blessed with a daughter who turned out pretty well I would say. We have been very blessed."
So far, Bill Clinton has not played any role in his wife's presidential campaign. But he is expected to be with Hillary Clinton when she holds the first rally of her campaign on Saturday.