In his three-minute-and-fifty-seconds video, the US President asked artists at the Grammys to urge their fans to join government's 'It's On Us' campaign targeted at college campuses, which began in September.
"Artists have a unique power to change minds and attitudes and get us talking about what matters," he said.
"It's on us, all of us, to create a culture where violence isn't tolerated, where survivors are supported and where all our young people men and women can go as far as their talents and their dreams will take them," Obama said.
After Obama's spot, activist Brooke Axtell told the story of her experience with domestic violence on the stage in a written-word performance.
Obama: Artists have a unique power to change minds and attitudes
"Authentic love does not devalue a human being. Authentic love does not silence, or shame or abuse," Axtell said, adding, "Your voice will save you... Let it set you free to know who you really are."
Her speech was followed by a performance of 'By the Grace of God' by Katy Perry.