According to officials, the drone fired four missiles on a compound in Dattakhel area, Dawn online reported.
On July 10, a US drone killed at least six people in North Waziristan.
The Pakistan government Thursday condemned the US drone strikes, saying these were counter-productive and unacceptable as they violated the country's sovereignty and territorial integrity.
The attacks were also harming the military operation "Zarb-i-Azb" in North Waziristan aimed at eliminating terrorism.
The last drone strike was June 18 killed at least eight militants.
On June 11, two successive drone strikes reportedly killed 16 people and injured a few others in Miranshah, the administrative headquarters of North Waziristan Agency.