The minister's convoy was caught up in a car pile-up following an accident on the Yamuna Expressway on Saturday in which one person died and two others were injured.
Now, one of the injured has accused the HRD minister of neglecting her injured father, who later succumbed to injury.
The victims told media persons that her father Dr Ramesh Nagar, who was going with two of his kids to attend a wedding, was hit by minister's convoy and succumbed to his injury.
The elder brother of the injured kids has filed an FIR against the minister for neglecting his father and siblings on the road and left in her cavalcade.
They have alleged that had minister helped them and sent Nagar to the hospital on time then their father could have been saved.
Irani, along with other Bharatiya Janata Party (BJP) leaders, was returning to Delhi from a meeting of the party's youth wing in Uttar Pradesh's Vrindavan town.
Irani took to Twitter to narrate her account of the accident and assure her supporters of her well-being.
"There was a pile up of vehicles due to an accident on the expressway. Unfortunately the police vehicle before mine and my car also crashed," she added.
The minister also said she helped those stranded on the expressway after the accident.
"Tried to help the injured who were lying on the road for quiet sometime and ensured they reach a hospital. Pray for their safety."
Earlier, last year, BJP MP from Mathura, Hema Malini got injured in a road accident in Dausa on Thursday while she was on her way to Jaipur from Agra. Hema Malini's Mercedes reportedly collided with an Alto car.The BJP MLA received head injuries and four people in Alto car also got severely injured.
4-year-old Sonam along with her family members was travelling in the Alto car collided with Malini's Mercedes. Unfortunately, Sonam succumbed to her injuries.
The girl's father had claimed that his child could have been saved if the MP was taken to hospital along with the actress.