All the 114 passengers on board reported safe, airport officials said.
The flight returned to the city airport after being airborne for over half-an-hour, they said.
The flight landed safely and it later departed for its destination after the problem was rectified.
"JetLite flight 9W1625, that had 114 passengers on board, took off at 5.47 AM but landed back at 6.20 AM due to port side engine failure," Mumbai airport spokesperson said.
The flight took off for Bhopal at 10.40 AM, the spokesperson said.
(with PTI inputs)