"It is with immense sorrow that we report our client, James Gandolfini passed away today while on holiday in Rome, Italy," managers Mark Armstrong and Nancy Sanders said in a joint statement. "Our hearts are shattered and we will miss him deeply. He and his family were part of our family for many years and we are all grieving."
The actor had been scheduled to make an appearance at the Taormina Film Fest in Sicily this week.
Gandolfini won three Emmy Awards for his portrayal of Tony Soprano, the angst-wracked mob boss who visited a therapist and took Prozac while knocking off people. "The Sopranos" aired from 1999 to 2007.