The quake is said to have occurred at 6.53 am. However, no reports of any casualties or damage of property has been reported so far.
According to the Regional Seismological Centre in Shillong, the epicentre was in Assam's Darrang district.
Besides Meghalaya and Assam, tremors were also felt in Manipur, Nagaland and Arunachal Pradesh.
Northeast India is considered the sixth major earthquake-prone belt in the world.
The Tuesday earthquake occurred when Assam and other parts of North-east are soaked in Rongali Bihu festivities. During the month-long harvest festival, revellers enjoy various food delicacies and soak themselves in song and dance numbers.
"I was having my morning cup of tea when I felt the tremor. I was about to come out of my house, but by that time the quake ended. Earthquakes are a regular affair in Assam and North-east. But, it still evokes fear in people," said Guwhati-based artist Lutfa Akhtar.