Barcelona have not suffered a home defeat in Europe for over three years and will hope their home form will help them overturn a two-goal deficit against the Italians.
The Catalans giants beat AC Milan in last season's quarter-finals and in the 2005-06 semi-finals. Many teams have recovered a from a single goal deficit but only none managed to overturn a deficit of two goals without the advantage of an away goal.
Barca will boosted by the return of influencial midfielder Xavi who recovered from a thigh injury, while Jordi Roura will recall several players who were rested for the win against Deportivo.
Mario Balotelli is cup-tied while striker Gaimpaolo Pazzini has missed the trip to Barcelona with a calf strain. Former Barcelona forward Bojan Krkic, Robinho and M'Baye Niang may replace him.
*Milan hold the record of crashing out despite having a 4-1 lead in the first-leg with Deportivo scoring 4-0 in the return leg.
*No team in the histotry of the Champions League has overcome a two-goal deficit.
*Barcelona record at home against Milan reads W3 D3 L1.
Barcelona (4-3-3): Valdes-Alves, Pique, Puyol, Alba-Busquets, Xavi, Iniesta-Fabregas, Pedro, Messi
Milan (4-3-3): Abbiati-Abate, Zapata, Mexes, Constant-Montolivo, Ambrosini, Muntari-Boateng, Niang, Shaarawy