Spurs did not enjoy great results against the Reds at Anfield. The Londoners last win came in May 2011, but is their only victory in the their last 18 visits to Anfield.
In recent years, Spurs have been the dominant force finishing above Liverpool. Spurs have also won seven and lost only three of their last 12 meetings in all competitions.
Gareth Bale, who has scored 14 goals in as many matches, will be key for Spurs' chances of finishing in the top-four and guarantee Champions League football. Luis Suarez, currently the top goal-scorer with 21 league goals, will consider his future depending on were Liverpool finish, but the positive impact of Daniel Sturridge and Phillipe Coutinho could prompt him to stay for longer.
Spurs are coming into this game after thrashing Inter Milan 3-0 at White Hart Lane on Thursday and will be confident following their derby win over Arsenal.
Liverpool are on a different level in 2013. The Reds have been winning on a record margin of three goals. Brendan Rodgers' side have scored 22 league goals in 2013, the highest tally in the league before this weekend.
Liverpool will be boosted with the return of Daniel Sturridge. The England international returned to training after a thigh injury while defender Martin Skrtel could make the bench after recovering from injury.
Tottenham could miss Aaron Lennon after suffering a hamstring strain against Inter Milan. Striker Emmanuel Adebayor returns after missing Thursday Europe League game with Inter Milan.
*Luis Suarez is the third player to have scored 20 league goals for Liverpool after Fernando Torres and Robbie Fowler.
*Tottenham have won four of their five games against Liverpool.
Liverpool (4-3-3): Reina-Johnson, Carragher, Agger, Enrique-Lucas, Gerrard, Allen-Suarez, Coutinho, Sturridge
Tottenham (4-2-3-1): Lloris-Walker, Vertongen, Dawson, Assou Ekotto-Dembele, Parker-Bale, Lennon, Siggurdson-Defoe