"News of blasts in Hyderabad is saddening. My condolences to the families of those who lost their lives. Praying for peace & calm there," Modi tweeted.
The blasts rocked a busy commercial hub of Hyderabad close to a crowded bus stand at Dilsukhnagar.
Meanwhile, police administration in Gujarat has been put on high alert in the wake of the explosions.
"We have asked all District Superintendents of Police (SPs) and city Police Commissioners to keep a tight vigil at crowded places like railway and bus stations, malls and markets," Director General of Police Chittaranjan Singh told PTI.
Gujarat's Anti-Terrorism Squad (ATS) and Intelligence Bureau (IB) of the state have been asked to be in contact with their counterparts in Hyderabad, he added.