Spurs are unbeaten in their last six league games while United have won nine out of their last 10 games. The league leaders are on 55 points after 22 points, the club's highest ever tally of any season.
The game at White Hart Lane is expected to be a cracker with both sides in great form. United are strong favourites to win but Spurs can be unpredictable with the likes of Gareth Bale, Jermain Defoe and Aaron Lennon.
United boss Sir Alex Ferguson has to make a decision whether or not to start Wayne Rooney while the return of Nani and Anderson should give extra strength upfront. United's defensive pair of Nemanja Vidic and Rio Ferdinand will be tested after playing only eight league matches in 17 months.
Spurs are stronger in defence under Andre Villas-Boas, recording seven wins and one loss in their last 10 league matches.
Despite the loss in September, United have the upperhand in this fixture, with 20 wins and 6 draws in the last 26 meetings in all competitions. Tottenham have not achieved the double over United since 1989-90 season.
Spurs midfielder may start replacing Sandro, who is sidelined for the rest of the season following knee surgery.
Portuguese winger Nani will be handed a start in place of Ashley Young, who is suffering from a knee injury.
*Spurs last beat Manchester United at White Hart Lane in May 2001.
*United have won eight league matches from losing positions.
*Robin van Persie has scored 65 goals in 77 league appearances and United have won all 14 games in which he has scored.
Tottenham Hotspur (4-4-2): Lloris-Walker, Dawson, Vertonghen, Naughton-Lennon, Parker, Dembele, Bale-Dempsey, Defoe.
Manchester United (4-4-2): De Gea-Rafael, Smalling, Ferdinand, Evra-Valencia, Carrick, Nani, Cleverley-Rooney, Van Persie.