The two clubs from the north-west of England are also the two most successful teams in England, together winning 119 titles, 60 for Manchester United and 59 for Liverpool.
Veteran United players Ryan Giggs and Paul Scholes consider Liverpool to be their biggest rivals. The two teams square up once again at Old Trafford on Sunday.
Liverpool are currently 21 points below their rivals but the difference wouldn't change the atmosphere in the stands or pitch. Regardless of form, injuries or weather, the 'north-west derby' will be a thriller.
Here is a look at some of the facts:
*Manchester United have won the league championship title 19 times while Liverpool have won 18 titles.
*The two English giants have met 185 times with 73 wins for Manchester United, 52 draws and 62 wins for Liverpool.
*Ryan Giggs has made the highest number of appearances with 43.
*The first match was played on Apr 28, 1894 which Liverpool won 2-0 against the Newton Heath.
*Liverpool's record at Anfield reads W38 D19 L23 and Manchester United's record at Old Trafford reads W39 D25 L15.
*United have scored 252 goals against the Reds while Liverpool have scored 235 times against the Manchester side.
*On average, atleast three goals are scored every time Manchester United and Liverpool play.
*Their most recent encounter in the Premier League went to Manchester United beating Liverpool 2-1 at Anfield.
*Liverpool dominated English football from 1973 to 1990, winning eleven league championships and four European Cups. Similarly, Manchester United have dominated English football since 1993, winning twelve league championships and two European Cups.